WASHINGTON (AP) ? Sen. John McCain says not to expect any surprises in this week's first presidential debate because the televised confrontations nowadays are so heavily scripted.
McCain was President Barack Obama's challenger in 2008. He says if he were running against Obama again, he could easily guess ? and prepare for ? the first half dozen questions because they are usually so obvious.
McCain says he still thinks debates are good for the country and the elections, and he predicted that Wednesday's debate between Obama and Republican Mitt Romney will attract the largest number of viewers in history. But, he says, if Americans are expecting to catch any revealing moments, they might be disappointed because "frankly the candidates are too well prepared."
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Australia vs South AfricaLive
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TIME: 17:00 local, 15:00 GMT
VENUE: Pretoria
DATE: Sat 29, September 2012
South Africa host Australia at Loftus Versveld on Saturday with both coaches feeling the pressure of their country?s expectation.
The Boks have won just one match so far in the Rugby Championship ? against tournament new boys Argentina ? and with back-to-back defeats against the All Blacks and Australia, Heyneke Meyer will be hoping his team re-find their best form against the Wallabies on Saturday. In front of their passionate Pretoria crowd and at altitude, the Boks hold all the trump cards.
The talk going into the match was dominated by out of form fly-half Morne Steyn. His heroics back in 2009 against the British & Irish Lions seem an eternity ago and the South African public have been calling for youngster Johan Goosen to be handed the half-back reigns instead of the Bulls man. Meyer has bowed to public pressure and has given the youngster the nod.
Wallabies coach Robbie Deans is also having issues with a fly-half, but an injured one. Quade Cooper has been on the front and back pages of the Australian press this week following his very public criticism of the Australian Rugby Union and the Wallabies set-up. Although he is adamant that he is supportive of Deans, labelling the camp as ?toxic? will do little to alleviate the pressure on the coach. The Australians have two wins in this Rugby Championship under their belt but their record of just two victories in 16 games against the All Blacks is all the ammo the Deans-doubters need.
South Africa ? Player to Watch: All eyes will be on the youngster Johan Goosen. He?s accurate with the boot, dangerous with ball in hand and seems to have a rugby brain far more advanced than his tender years. He will either revel or collapse in the Loftus Versveld cauldron ? fans of the Springboks will hope that he embraces the atmosphere and produces a match-winning performance.
South Africa ? Team News: Goosen?s inclusion at the expense of Morne Steyn is one of three changes from the team that lost to the All Blacks in their last match. Andries Bekker and Eben Etzebeth both start in the second-row while there are four changes to the replacements. Coenie Oosthuizen, Flip van der Merwe, Elton Jantjies and Jaco Taute are all included ? Taute may yet get the nod in the first XV with Frans Steyn an injury doubt.
Australia ? Player to Watch: Kurtley Beale starts his first match in the fly-half berth for the Wallabies. With friend and Wallabies colleague Cooper taking all the headlines, Beale will hope to deflect the attention away from the Reds playmaker and back on to the field for all the right reasons. There is no doubt that Beale is an immensely talented player, but he is out of form and will need to harness all of his ability come Saturday.
Australia ? Team News: Beale has been handed the No.10 shirt with Nick Phipps remaining at scrum-half. Berrick Barnes switches to fullback while the team will be captained by Nathan Sharpe. Kane Douglas retains his place in the second-row in what will be his second Test for the Wallabies with Sitaleki Timani failing to recover from a hamstring strain. Reds second rower Rob Simmons comes in on a bench which features five forwards, while the evergreen Western Force halfback Brett Sheehan is one of two back reserves, alongside Anthony Fainga?a.
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CEDAR RAPIDS, Iowa - 'On Iowa Live' welcomed Iowa assistant men's basketball coach Kirk Speraw to Monday's program, and Speraw and the guys talked about Iowa men's basketball's 2012 season outlook and Speraw's playing days at Iowa.
Before Speraw joined the show, TV9's Scott Saville and Scott Dochterman, Mike Hlas and Marc Morehouse of The Gazette talked about Iowa's loss to Central Michigan, Iowa State's unbeaten match-up with Texas Tech and plenty more.
Part 1 - Iowa/CMU recap, and a breakdown of the botched onside kick:
Part 2 - The guys welcome Kirk Speraw to the program:
Part 3 - Speraw talks about his 2012 Hawkeye basketball team and the team's new players, including freshman Mike Gesell:
It seems like pretty much everyone these days is jumping on top of the online auction bandwagon. Almost every day a brand new auction website is released and shoppers flock towards it in search of ever greater bargains.
But why are live auctions so popular? Well, this is one of the bigger questions surrounding online auctions, and not one which we could hope to answer completely in the limited time and space we have available to us. But allow us to at least have a go at covering some of the basics.
The term "live auction" is used to describe a lot on an auction website which is still open for new bids. In other words the auction is still live and the sale has not yet been finalised. Almost every auction website now conforms to a system whereby the auctioneers will also give you a handy little countdown clock, which will tell you exactly when this auction will cease to be live. When the time on that clock has counted down to 0, there will be no more bidding permitted on that lot and the online auction will close.
This countdown is one of the things that contribute towards making live auctions so popular. The fact that shoppers and would be bidders can go onto any auction website and see a useful clock which tells them how much longer they have if they wish to bid on the lot, is a common theme which consumers love to see. A live countdown like this is a great way to build up an excitement and a buzz around an online auction. Just ask any online shopper who uses an auction website, and they will all tell you the same thing. That the dying moments of a live auction are some of the most exciting moments in the online shopping experience.
Many online shoppers and bidders say that the excitement and anticipation which they experience in the closing seconds of an online auction, is the single biggest element which keeps them coming back. And of course, this build up of excitement is only made possible thanks to the presence of the countdown clock.
Sitting and watching the final seconds count down and wondering whether you are going to be lucky enough to win the lot, or whether a rival bidder will come in and pip you at the post, is what makes live auctions so exciting to be a part of.
Realistically however, if you came into this article wondering why live auctions are so popular among online shoppers, then the chances are you already know the answer to this. The fact is that if you have ever pondered this question, then you are likely as not, just as big an online bidder as the rest of us! Of course, there are many, many more things which contribute towards making live auctions on an auction website so popular. But what it all ultimately boils down to is the blend it provides between entertainment and shopping.
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Below are the three companies in the Electronic Manufacturing Services industry with the highest debt to equity ratios. The Debt/Equity ratio measures a company's leverage and a high level often implies that a company has financed much of its growth with debt.
Sanmina-SCI ranks highest with a a debt to equity ratio of 1.2. Following is Kemet with a a debt to equity ratio of 1.1. Flextronics International ranks third highest with a a debt to equity ratio of 1.0.
Jabil Circuit follows with a a debt to equity ratio of 0.8, and SMTC rounds out the top five with a a debt to equity ratio of 0.8.
SmarTrend recommended that its subscribers protect gains by selling shares of Jabil Circuit on September 4th, 2012 by issuing a Downtrend alert when the shares were trading at $21.66. Since that call, shares of Jabil Circuit have fallen 13.6%. We are now looking for when a new Uptrend will commence and will alert SmarTrend subscribers in real time.
Keywords: highest debt to equity ratio sanmina-sci amex:kem kemet flextronics international Jabil Circuit nasdaq:smtx
FILE - In this Sept. 15, 2012 file image from video provided by CBS2-KCAL9, Nakoula Basseley Nakoula, the man behind a crudely produced anti-Islamic video that has inflamed parts of the Middle East, is escorted by Los Angeles County sheriff's deputies from his home in Cerritos, Calif. Nakoula, 55, was arrested Thursday for violating terms of his probation, authorities said. (AP Photo/CBS2-KCAL9, File) MANDATORY CREDIT CBS-KCAL9, LOS ANGELES OUT, LOS ANGELES TV OUT
FILE - In this Sept. 15, 2012 file image from video provided by CBS2-KCAL9, Nakoula Basseley Nakoula, the man behind a crudely produced anti-Islamic video that has inflamed parts of the Middle East, is escorted by Los Angeles County sheriff's deputies from his home in Cerritos, Calif. Nakoula, 55, was arrested Thursday for violating terms of his probation, authorities said. (AP Photo/CBS2-KCAL9, File) MANDATORY CREDIT CBS-KCAL9, LOS ANGELES OUT, LOS ANGELES TV OUT
This courtroom sketch shows Nakoula Basseley Nakoula talking with his attorney Steven Seiden, left, in court Thursday Sept. 27, 2012. The U.S. Central District Chief Magistrate Judge Suzanne Segal on Thursday determined the California man behind a crudely produced anti-Islamic video that inflamed parts of the Middle East is a flight risk and ordered him detained. (AP Photo/Mona Shafer Edwards)
This courtroom sketch shows Nakoula Basseley Nakoula talking with his attorney Steven Seiden, left, as U.S. Central District Chief Magistrate Judge Suzanne Segal presides over the proceeding Thursday Sept. 27, 2012. The federal judge on Thursday determined the California man behind a crudely produced anti-Islamic video that inflamed parts of the Middle East is a flight risk and ordered him detained. (AP Photo/Mona Shafer Edwards)
This courtroom sketch shows Nakoula Basseley Nakoula talking with his attorney Steven Seiden, left, in court Thursday Sept. 27, 2012. The U.S. Central District Chief Magistrate Judge Suzanne Segal on Thursday determined the California man behind a crudely produced anti-Islamic video that inflamed parts of the Middle East is a flight risk and ordered him detained. (AP Photo/Mona Shafer Edwards)
U.S. Federal marshals drive away in a vehicle believed to be carrying Nakoula Basseley Nakoula after his arraignment in federal court in Los Angeles Thursday, Sept. 27, 2012. A federal judge on Thursday ordered Nakoula, the man behind a crudely produced anti-Islamic video that inflamed parts of the Middle East to be detained because he is a flight risk and for violating terms of hisprobation. (AP Photo/Damian Dovarganes)
LOS ANGELES (AP) ? The mystery surrounding the man behind the crudely produced anti-Islamic video that sparked violence in the Middle East deepened when he appeared in court and identified himself by yet another name.
Arrested on Thursday in Los Angeles after authorities said he violated his probation from a 2010 check fraud conviction, Nakoula Basseley Nakoula told a judge his real name was Mark Basseley Youssef. He said he had been using that name since 2002, even though he went by Nakoula in his fraud case.
Court documents filed in Orange County Superior Court show he was granted a name change petition in 2002 and legally changed his name to Mark Basseley Youssef because "Nakoula is a girl's name and it cause me troubles."
On Friday, federal prosecutors said court documents will now reflect Youssef's real name. Assistant U.S. Attorney Robert Dugdale said Youssef didn't give that name when he was charged two years ago. Also, he had a driver's license under Nakoula, authorities said.
"He did not provide his true legal name at the time of prosecution," Dugdale said.
The full story about Youssef and the video "Innocence of Muslims" still isn't known more than two weeks after violence erupted in Egypt and elsewhere in the Arab world where at least 50 people have died in protests related to the film.
Citing a lengthy pattern of deception and the potential to flee, U.S. Central District Chief Magistrate Judge Suzanne Segal ordered Youssef to remain in prison without bond until another judge can hold a hearing to determine if he broke the terms of his probation.
"The court has a lack of trust in this defendant at this time," Segal said.
Prosecutors noted Youssef had eight probation violations, including lying to his probation officers and using aliases. He could face new charges that carry a maximum two-year prison term.
After his 2010 conviction, Youssef was sentenced to 21 months in prison and was barred from using computers or the Internet for five years without approval from his probation officer, though prosecutors said none of the violations involved the Internet. He also wasn't supposed to use any name other than his true legal name without the prior written approval of his probation officer.
Three names, however, have been associated with Youssef this month alone.
The movie was made last year by a man who called himself Sam Bacile. After the violence erupted, a man who identified himself as Bacile spoke to media outlets including The Associated Press, took credit for the film and said it was meant to portray the truth about Muhammad and Islam, which he called a cancer.
The next day, the AP determined there was no Bacile and linked the identity to Nakoula Nakoula, a former gas station owner with a drug conviction and a history of using aliases. Federal authorities later confirmed there was no Bacile and that Nakoula was behind the movie.
Some of the false statements in Youssef's alleged probation violations had to do with the film, Dugdale said. Youssef told probation officials his role was just writing the script, and denied going by the name Sam Bacile in connection with the film, Dugdale said.
Before going into hiding, Youssef acknowledged to the AP that he was involved with the film but said he only worked on logistics and management.
Youssef, a Christian originally from Egypt, then went into hiding after he was identified as the man behind the trailer, which depicts Muhammad as a womanizer, religious fraud and child molester. He met with federal probation officials two weeks ago, was led out of his home in suburban Cerritos in the middle of the night, flanked by Los Angeles County sheriff's deputies and cloaked in heavy clothing to protect his identity.
Youssef came out of hiding Thursday for his court appearance, although the news media were banned from the courtroom and reporters had to watch the proceedings on a TV in a nearby courthouse. No photos were allowed.
Youssef wore beige pants and a collared shirt when he was led into the courtroom handcuffed and shackled. He appeared relaxed, smiling at one point before the hearing and conferring with his attorney.
Youssef's attorney, Steven Seiden, sought to have the hearing closed and his client released on $10,000 bail. He argued Youssef has checked in with his probation officer frequently and made no attempts to leave Southern California.
Seiden was concerned that Youssef would be in danger in federal prison because of Muslim inmates, but prosecutors said he likely would be placed in protective custody.
Lawrence Rosenthal, a constitutional and criminal law professor at Chapman University School of Law in Orange, said it was "highly unusual" for a judge to order immediate detention on a probation violation for a nonviolent crime, but if there were questions about Youssef's identity it was more likely.
"When the prosecution doesn't really know who they're dealing with, it's much easier to talk about flight," Rosenthal said. "I've prosecuted individuals who'd never given a real address. You don't know who you're dealing with, and you're just going to have very limited confidence about their ability to show up in court."
Enraged Muslims have demanded punishment for Youssef, and a Pakistani cabinet minister has offered a $100,000 bounty to anyone who kills him.
First Amendment advocates have defended Youssef's right to make the film while condemning its content. Federal officials likely will face criticism from those who say Youssef's free speech rights were trampled by his arrest on a probation violation.
In arguing that Youssef is a possible flight risk, Dugdale said Youssef couldn't even reveal something as fundamental as his real name.
"He's a person who simply can't be trusted," he said.
___
Associated Press writers Gillian Flaccus and Amy Taxin in Orange County, Calif. contributed to this report.
Scott Stein is editor of When Falls the Coliseum and author of the novels Lost and Mean Martin Manning. His short fiction, book reviews, and essays have been published in the Philadelphia Inquirer, The G.W. Review, Liberty, National Review, PopMatters.com, and Art Times. He is an associate teaching professor of English at Drexel University.
SpellTower ($1.99), a wonderful iPhone and iPad game, has been featured in our "75 Best iPad Games" and "20 Awesome Full-Screen iPhone 5 Apps" articles. But while writing that latter story, I realized that I had never formally reviewed this wonderful brain parasite of a word game.?
Let's remedy that.
I'll slap 4.5 stars and an Editor's Choice on this addictive little time-waster. SpellTower combines attributes of Boggle and Tetris, but it's the fit and finish, the elegant color scheme and fonts (as shown at right), that really make it stand out from the masses.
SpellTower has a few different modes. In one, you try to draw words formed from letters on a grid. In the others, you draw your words, but the grid builds from the bottom and increases by a line every turn; if it fills up the screen, the game is over. "Rush mode" adds lines every few seconds rather than each turn. Some letters will clear a whole row, and some can't be used unless you're making longer words. As the game goes on, it demands more five- and six-letter words.
The iPhone and iPad versions have different sized grids; the iPad has a larger grid with more rows, making the game longer. The iPhone 5 uses the iPad's grid, so you get to take advantage of all that extra-long-screen goodness.
Multiplayer mode is strictly local, played between phones or iPads connected via Bluetooth. That's fine with me, but online connectivity would be the next logical step here.
Since I'm now playing this game during every commute, why not give it five stars? SpellTower has some minor issues with touch targets on the full-screen iPhone 5 grid. You may have to tap some letters twice. That's all.
If you like spelling, buy SpellTower.
For more iPhone Software, see:
??? SpellTower (for iPhone and iPad) ??? Polaris Office (for iPhone) ??? Star Walk 6.0 (for iPhone) ??? Ness Dining Guide (for iPhone) ??? Apple iOS 6 ?? more
PHILADELPHIA (AP) ? Mitt Romney is set to speak by telephone with Israeli Prime Minister Benjamin Netanyahu (neh-ten-YAH'-hoo) on Friday.
The Republican presidential nominee's campaign confirms the scheduled conversation. It would come the same day that President Barack Obama also is expected to speak with Netanyahu phone.
The economy has dominated the presidential contest so far, but both candidates have focused more on foreign policy in recent weeks.
Romney has been critical of Obama's relationship with Israel's leadership.
Netanyahu told the United Nations on Thursday that tougher action is needed to prevent Iran from developing nuclear weapons. The prime minister argues that an attack on Iran's nuclear facilities may be the only answer.
Obama and Romney support the use of military force if necessary to prevent Iran from possessing a nuclear weapon.
Exxon Mobil and Rosneft are planning to drill for oil in the?Kara Sea, which the Soviet Union used as a dumping ground for radioactive material for more than 25 years, according to OilPrice.com.?
By James Burgess,?Guest blogger / September 27, 2012
A view of the Exxon Mobil refinery in Baytown, Texas, in this September 2008 file photo. Exxon Mobil and Rosneft are planning to drill in a former nuclear dump which is estimated to hold enough oil to supply the world for five years, Burgess writes.
Jessica Rinaldi/Reuters/File
Enlarge
It has been well documented that oil majors from around the world are looking at oil exploration in the Arctic, where they believe that some of the largest untapped fields in the world still lie. Environmentalists have been fighting efforts to start exploring for oil, fearing that any serious oil spill could mean the destruction of one of the last pristine wildernesses on the planet.
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offers extensive coverage of all energy sectors from crude oil and natural gas to solar energy and environmental issues. To see more opinion pieces and news analysis that cover energy technology, finance and trading, geopolitics, and sector news, please visit?Oilprice.com.
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In the Kara Sea, where Exxon Mobil and Rosneft are planning to drill a region which is estimated to hold enough oil to supply the world for five years, environmentalists have a new reason to fear for the environment; nuclear radiation.?(RELATED:?Oil is Not Looking So Hot)
The Kara Sea is so remote that the Soviet Union used it as a dumping ground for radioactive material for more than 25 years. The two oil companies have avoided calls for the nuclear waste, estimated to consist of over 17,000 barrels of radioactive waste, worn-out reactors, and even an old nuclear submarine, to be cleared up before any exploration takes place. Scientists from the Norwegian Radiation Protection Authority (NRPA) will soon present the results from their first survey in the area for 18 years, to determine whether or not the radiation is stable or increasing. Rosneft released a statement to try and reassure the public that??all ecological and nature protection norms are being followed at the same time,? using ?the the best world practices available.?
The most dangerous item down on the sea floor in that area is the K-27 nuclear submarine, which was dumped their by the Soviet navy in 1981. The NRPA said that any significant corrosion could damage the ships reactor and cause an environmental disaster. (RELATED:?Big Oil Funding U.S. Politics) Per Strand, a director at the NRPA, warned that??there might be a hypothetical possibility that the spent nuclear fuel in the reactor in extreme situations can cause an uncontrolled chain reaction, which can lead to heat and radioactivity releases.? Igor Kudrik, an ecologist from Norwegian campaign group Bellona, suggests that??oil companies should make sure that the area is swiped clean of nuclear waste before they start any oil exploration activity.?
The Christian Science Monitor has assembled a diverse group of the best energy bloggers out there. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger, click here. To add or view a comment on a guest blog, please go to the blogger's own site by clicking on the link in the blog description box above.
HUM, distributed nearly $20 million to physicians across the U.S. who participated in the Humana Provider Quality Rewards Program in 2011, the program?s second year.
Humana Inc. (NYSE: HUM), headquartered in Louisville, Ky., is a leading health-care company that offers a wide range of insurance products and health and wellness services that incorporate an integrated approach to lifelong well-being. By leveraging the strengths of its core businesses, Humana believes it can better explore opportunities for existing and emerging adjacencies in health care that can further enhance wellness opportunities for the millions of people across the nation with whom the company has relationships. For more information about Humana Inc. visit www.humana.com.
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Freescale Semiconductor (NYSE:FSL)
FSL?s award-winning Kinetis L series, the world?s most energy-efficient microcontrollers (MCUs) and the first built on the ARM? Cortex?-M0+ processor, is now broadly available.
Kinetis L series 32-bit devices, initially announced earlier this year, are the first to be featured on the new Freescale Freedom development platform, a small, low-power, cost-effective evaluation and development system perfect for quick application prototyping and demonstration.
Freescale Semiconductor (NYSE: FSL) is a global leader in embedded processing solutions, providing industry leading products that are advancing the automotive, consumer, industrial and networking markets. From microprocessors and microcontrollers to sensors, analog integrated circuits and connectivity ? our technologies are the foundation for the innovations that make our world greener, safer, healthier and more connected. Some of our key applications and end-markets include automotive safety, hybrid and all-electric vehicles, next generation wireless infrastructure, smart energy management, portable medical devices, consumer appliances and smart mobile devices. FSL is based in Austin, Texas, and has design, research and development, manufacturing and sales operations around the world. www.freescale.com.
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Crown Equity Holdings Inc. (CRWE)
CRWE has launched a online service companies CRWE Real Estate. CRWE launched CRWE Real Estate to provide a global portal for property listings at a fee of only $1 a day. CRWE Real Estate (www.crwerealestate.com)mission is to empower consumers with information and tools to make smart decisions about homes, real estate and mortgages.
CRWE offers advertising branding and marketing services as a worldwide online multi-media publisher with its digital network of websites and focuses on the distribution of information for the purpose of bringing together a targeted audience and the advertisers that want to reach them. Crown Equity Holdings advertising services cover and connect a range of marketing specialties, as well as provide search engine optimization for clients interested in online media awareness. For more information about Crown Equity Holdings Inc. visit www.crownequityholdings.com.
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Optical mammography sheds new light on breast cancer Public release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Alex Reid Alexander.Reid@tufts.edu 617-627-4173 Tufts University
Tufts tests new technology that could aid in breast cancer diagnosis & treatment
MEDFORD/SOMERVILLE, Mass. New optical imaging technology developed at Tufts University School of Engineering could give doctors new ways to both identify breast cancer and monitor individual patients' response to initial treatment of the disease. A five-year clinical study of the procedure, funded by a $3.5 million grant from the National Institutes of Health, is now underway at Tufts Medical Center in Boston.
The non-invasive technology uses near infrared (NIR) light to scan breast tissue, and then applies an algorithm to interpret that information. Differences in light absorption allow identification of water, fats, and oxygen-rich and oxygen-poor tissue, the primary structures in breast tissue.
"The consensus is that x-ray mammography is very good at detecting lesions but it's not as good at determining which suspicious lesions are really cancer," says Professor of Biomedical Engineering Sergio Fantini, Ph.D., who is leading the research effort. The Tufts NIR technique could complement standard mammography, particularly for women younger than 40 who may have dense breast tissue that tends to obscure detail in x-rays.
Because it does not use ionizing radiation, the NIR technique can be applied multiple times over a short period without risk of radiation exposure, Fantini notes. Another advantage of the technology is that, unlike other breast imaging methods, it can obtain functional real-time images of metabolic changes, such as levels of hemoglobin concentration and oxygenation.
"It's been reported that patients who respond to breast cancer chemotherapy show a decrease in hemoglobin and water concentration and an increase in lipid concentration at the cancer site," explains Fantini. "This suggests that NIR imaging can be valuable not only in diagnosing breast cancer but in monitoring individual response to therapies without requiring repeated x-rays. For example, it could help determine if a patient is responding to neoadjuvant chemotherapy administered to shrink a tumor before surgery."
Optical mammography is also more comfortable than traditional mammograms. The patient's breasts are only lightly compressed between two horizontal glass panels and then illuminated by NIR light. A specialized software program displays real-time images of the breast as the optical system scans back and forth. A light detector within the system displays the intensity of the NIR beam as it is transmitted through the breast.
By using an algorithm based on the optical information, the technology generates breast images using the intensity of the transmitted light. The images are displayed automatically and can be read soon after the procedure, as is the case with x-ray mammograms. The technology can be packaged into compact, portable and handheld devices.
Clinical Testing
In collaboration with Roger Graham, M.D., director of Tufts Medical Center's Breast Health Center, and Marc Homer, M.D., chief of mammography at Tufts Medical Center, Fantini and his team conducted "proof of concept" tests to see if their procedure could corroborate information gathered with x-rays on two patients who each had suspicious lesions in one of their breasts.
The optical imaging was successful in enabling the team to identify cancerous tissue. "The test results were compatible with what we found in the x-ray mammography," Graham explains. "It was also painless for the patients and eliminated radiation exposure."
The team also includes Eric Miller, Ph.D., professor and chair of electrical and computer engineering and Misha Kilmer, Ph.D., professor of mathematics within the School of Arts and Sciences.
The NIH-funded study will investigate healthy women, women with breast cancer and women with benign breast lesions in an effort to examine the effectiveness of optical mammography in detecting breast cancer and distinguishing between malignant and benign tumors. The study will also look at breast cancer patients who are undergoing chemotherapy in order to characterize the power of optical mammography to determine patient response at the beginning of therapeutic treatment.
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Fantini and his colleagues have published numerous papers on optical mammography: http://ase.tufts.edu/biomedical/research/fantini/publications/opticalMammography.asp.
This research is listed under award number 5R01CA154774-02
About Tufts University School of Engineering
Located on Tufts' Medford/Somerville campus, the School of Engineering offers a rigorous engineering education in a unique environment that blends the intellectual and technological resources of a world-class research university with the strengths of a top-ranked liberal arts college. Close partnerships with Tufts' excellent undergraduate, graduate and professional schools, coupled with a long tradition of collaboration, provide a strong platform for interdisciplinary education and scholarship. The School of Engineering's mission is to educate engineers committed to the innovative and ethical application of science and technology in addressing the most pressing societal needs, to develop and nurture twenty-first century leadership qualities in its students, faculty, and alumni, and to create and disseminate transformational new knowledge and technologies that further the well-being and sustainability of society in such cross-cutting areas as human health, environmental sustainability, alternative energy, and the human-technology interface.
About Tufts Medical Center and Floating Hospital for Children Tufts Medical Center is an exceptional, not-for-profit, 415-bed academic medical center that is home to both a full-service hospital for adults and Floating Hospital for Children. Conveniently located in downtown Boston, the Medical Center is the principal teaching hospital for Tufts University School of Medicine. Floating Hospital for Children is the full-service children's hospital of Tufts Medical Center and the principal pediatric teaching hospital of Tufts University School of Medicine. Tufts Medical Center is affiliated with seven community hospitals and with New England Quality Care Alliance, its community physicians' network.
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Optical mammography sheds new light on breast cancer Public release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Alex Reid Alexander.Reid@tufts.edu 617-627-4173 Tufts University
Tufts tests new technology that could aid in breast cancer diagnosis & treatment
MEDFORD/SOMERVILLE, Mass. New optical imaging technology developed at Tufts University School of Engineering could give doctors new ways to both identify breast cancer and monitor individual patients' response to initial treatment of the disease. A five-year clinical study of the procedure, funded by a $3.5 million grant from the National Institutes of Health, is now underway at Tufts Medical Center in Boston.
The non-invasive technology uses near infrared (NIR) light to scan breast tissue, and then applies an algorithm to interpret that information. Differences in light absorption allow identification of water, fats, and oxygen-rich and oxygen-poor tissue, the primary structures in breast tissue.
"The consensus is that x-ray mammography is very good at detecting lesions but it's not as good at determining which suspicious lesions are really cancer," says Professor of Biomedical Engineering Sergio Fantini, Ph.D., who is leading the research effort. The Tufts NIR technique could complement standard mammography, particularly for women younger than 40 who may have dense breast tissue that tends to obscure detail in x-rays.
Because it does not use ionizing radiation, the NIR technique can be applied multiple times over a short period without risk of radiation exposure, Fantini notes. Another advantage of the technology is that, unlike other breast imaging methods, it can obtain functional real-time images of metabolic changes, such as levels of hemoglobin concentration and oxygenation.
"It's been reported that patients who respond to breast cancer chemotherapy show a decrease in hemoglobin and water concentration and an increase in lipid concentration at the cancer site," explains Fantini. "This suggests that NIR imaging can be valuable not only in diagnosing breast cancer but in monitoring individual response to therapies without requiring repeated x-rays. For example, it could help determine if a patient is responding to neoadjuvant chemotherapy administered to shrink a tumor before surgery."
Optical mammography is also more comfortable than traditional mammograms. The patient's breasts are only lightly compressed between two horizontal glass panels and then illuminated by NIR light. A specialized software program displays real-time images of the breast as the optical system scans back and forth. A light detector within the system displays the intensity of the NIR beam as it is transmitted through the breast.
By using an algorithm based on the optical information, the technology generates breast images using the intensity of the transmitted light. The images are displayed automatically and can be read soon after the procedure, as is the case with x-ray mammograms. The technology can be packaged into compact, portable and handheld devices.
Clinical Testing
In collaboration with Roger Graham, M.D., director of Tufts Medical Center's Breast Health Center, and Marc Homer, M.D., chief of mammography at Tufts Medical Center, Fantini and his team conducted "proof of concept" tests to see if their procedure could corroborate information gathered with x-rays on two patients who each had suspicious lesions in one of their breasts.
The optical imaging was successful in enabling the team to identify cancerous tissue. "The test results were compatible with what we found in the x-ray mammography," Graham explains. "It was also painless for the patients and eliminated radiation exposure."
The team also includes Eric Miller, Ph.D., professor and chair of electrical and computer engineering and Misha Kilmer, Ph.D., professor of mathematics within the School of Arts and Sciences.
The NIH-funded study will investigate healthy women, women with breast cancer and women with benign breast lesions in an effort to examine the effectiveness of optical mammography in detecting breast cancer and distinguishing between malignant and benign tumors. The study will also look at breast cancer patients who are undergoing chemotherapy in order to characterize the power of optical mammography to determine patient response at the beginning of therapeutic treatment.
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Fantini and his colleagues have published numerous papers on optical mammography: http://ase.tufts.edu/biomedical/research/fantini/publications/opticalMammography.asp.
This research is listed under award number 5R01CA154774-02
About Tufts University School of Engineering
Located on Tufts' Medford/Somerville campus, the School of Engineering offers a rigorous engineering education in a unique environment that blends the intellectual and technological resources of a world-class research university with the strengths of a top-ranked liberal arts college. Close partnerships with Tufts' excellent undergraduate, graduate and professional schools, coupled with a long tradition of collaboration, provide a strong platform for interdisciplinary education and scholarship. The School of Engineering's mission is to educate engineers committed to the innovative and ethical application of science and technology in addressing the most pressing societal needs, to develop and nurture twenty-first century leadership qualities in its students, faculty, and alumni, and to create and disseminate transformational new knowledge and technologies that further the well-being and sustainability of society in such cross-cutting areas as human health, environmental sustainability, alternative energy, and the human-technology interface.
About Tufts Medical Center and Floating Hospital for Children Tufts Medical Center is an exceptional, not-for-profit, 415-bed academic medical center that is home to both a full-service hospital for adults and Floating Hospital for Children. Conveniently located in downtown Boston, the Medical Center is the principal teaching hospital for Tufts University School of Medicine. Floating Hospital for Children is the full-service children's hospital of Tufts Medical Center and the principal pediatric teaching hospital of Tufts University School of Medicine. Tufts Medical Center is affiliated with seven community hospitals and with New England Quality Care Alliance, its community physicians' network.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Asiatic cheetahs snatch livestock Asiatic cheetahs, one of the world's most endangered animals, are forced to eat livestock in areas where their wild prey is in decline, a study finds.
Source: BBC News Posted on:
Wednesday, Sep 26, 2012, 8:10am Views: 13
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I'll slap 4.5 stars and an Editor's Choice on this addictive little time-waster. SpellTower combines attributes of Boggle and Tetris, but it's the fit and finish, the elegant color scheme and fonts (as shown at right), that really make it stand out from the masses.
Humana Inc. (NYSE:HUM)
Freescale Semiconductor (NYSE:FSL)
Crown Equity Holdings Inc. (CRWE)
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Public release date: 27-Sep-2012
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