Sunday, October 20, 2013

Parks open, workers back in office after shutdown

Yosemite Park Ranger Ron Morton takes a payment from a visitor at the front gate after the reopening of Yosemite National Park, Calif., Thursday, Oct. 17, 2013. The park reopened Wednesday night with the end of the 16-day partial government shutdown. (AP Photo/Gary Kazanjian)







Yosemite Park Ranger Ron Morton takes a payment from a visitor at the front gate after the reopening of Yosemite National Park, Calif., Thursday, Oct. 17, 2013. The park reopened Wednesday night with the end of the 16-day partial government shutdown. (AP Photo/Gary Kazanjian)







Visitors at Tunnel View, like Kaori Nishimura and Eriko Kuboi, from Japan, pose in front of Half Dome, center facing, during the reopening of Yosemite National Park, Calif., Thursday, Oct. 17, 2013. Tunnel View is a scenic vista which shows off El Capitan, Half Dome and Bridalveil Fall. The park reopened Wednesday night with the end of the 16-day partial government shutdown. (AP Photo/Gary Kazanjian)







People form a tour group at the Smithsonian's Air and Space Museum in Washington, Thursday, Oct. 17, 2013. Barriers went down at federal memorials, National Park Service sites, as well as the Smithsonian Institution's network of popular museums and thousands of furloughed federal workers returned to work across the country Thursday after 16 days off the job due to the partial government shutdown. (AP Photo/Cliff Owen)







Farmer Kevin Scott unloads a truckload of soybeans Thursday, Oct. 17, 2013, on his land near Valley Springs, S.D. He said most farmers are more focused on harvesting than the government reopening but they are concerned Congress hasn’t passed a new farm bill. (AP Photo/Carson Walker)







White House Chief of Staff Denis McDonough, center, greets federal employees at the entrance to the Eisenhower Executive Office Building as he they return to the White House in Washington, Thursday, Oct. 17, 2013. Lawmakers Wednesday voted to avoid a financial default and reopen the government after a 16-day partial shutdown. (AP Photo/Charles Dharapak)







From the Liberty Bell to Alcatraz, federal landmarks and offices reopened Thursday. Furloughed employees were relieved to get back to work — even if faced with email backlogs — but many worried about another such disruption in a matter of months.

"We'd hate to have to live through this all over again," Richard Marcus, a 29-year employee of the National Archives in Washington, said after the government shutdown finally ended.

Nationwide, from big-city office buildings to wilderness outposts, innumerable federal services and operations shifted back into gear after 16 days.

The U.S. Forest Service started lifting a logging ban on national forests. U.S. Citizenship and Immigration Services restarted the computerized system used to verify the legal status of workers. Boat trips resumed to Alcatraz, the former federal prison in San Francisco Bay, with 1,600 tickets snapped up by tourists in the first hour of business.

In Alaska, federal officials rushed to get the red king crab fishing season underway. The opening had been delayed because furloughed workers were not around to issue crab-quota permits.

National Park Service Director Jonathan Jarvis said all 401 national park units — from the Golden Gate National Recreation Area in California to Acadia National Park in Maine — were reopening Thursday.

More than 20,000 National Park Service employees had been among the 800,000 federal workers sent home at the peak of the shutdown.

Visitors from around the world flocked to Yosemite National Park to see such famous sites as El Capitan and Half Dome after weeks of closure brought local economies to a near standstill.

At Yellowstone and Grand Teton national parks, employees were busy with reopening chores. They returned just in time to begin closing the parks up again for the winter in a couple of weeks.

At Philadelphia's Independence National Historical Park, one couple's long wait to see the Liberty Bell and other attractions finally drew to a close.

Karen and Richard Dodds of Oklahoma City were on a quest to see every national park in the U.S. They arrived in Philadelphia about three weeks ago in their motor home, visiting Valley Forge just before the shutdown. They stayed on in the area, awaiting a settlement.

"They didn't solve anything by this," Katie Dodds said of the temporary agreement in Congress that funds the government only through Jan. 15 and gives it the borrowing authority it needs only through Feb. 7. "The worst part is they'll do it again in January and February."

Among the many sites reopening in Washington were the Smithsonian Institution's museums and the World War II memorial on the National Mall, which had been the scene of protests over the shutdown.

Smithsonian spokeswoman Linda St. Thomas said the museum complex lost about $2.8 million in revenue during the shutdown.

The National Zoo was set to reopen Friday, though its popular panda cam went live Thursday morning, giving fans a view of a cub wriggling about as its mother, Mei Xiang, tucked her paws under her chin and watched.

Federal workers who were furloughed or worked without pay during the shutdown will get back pay in their next paychecks, which for most employees come Oct. 29.

Labor Secretary Thomas Perez greeted returning workers with a sympathetic email.

"Unfortunately, as President Obama correctly noted, you are occasionally called on to perform your remarkably important work in a climate that too often treats federal employees and contractors as a punching bag," Perez said.

The Defense Department called back about 7,000 furloughed civilians. In an open letter to the workforce, Defense Secretary Chuck Hagel said the department still faces budget uncertainty as Congress struggles to pass a 2014 spending bill and deal with automatic budget cuts. Pentagon Comptroller Robert Hale said the department lost at least $600 million worth of productivity during the four days that civilians were furloughed.

The National Institutes of Health warned university scientists not to expect a quick resumption of research dollars.

At the National Institute of Standards and Technology in Gaithersburg, Md., email servers were slowly grinding back into gear.

Fire protection engineer Dan Madrzykowski had been in the office for about half an hour and about 800 emails had popped into his inbox. And that represented less than a week of the shutdown. Still, Madrzykowski said he was pleased to be back.

"Nothing good was coming from keeping the government closed," he said.

Patrice Roberts, who works for Homeland Security, said she wasn't prepared for the emotional lows of the past 16 days.

"It's just frustrating having that kind of control over your life and just having it taken away from me," said Roberts, who is expecting another shutdown in January. "I'll be better prepared next time."

In Pottsville, Pa., several people waited outside the Social Security office ahead of its 9 a.m. opening. James Ulrich, an unemployed 19-year-old, needed a replacement for his lost Social Security card to apply for jobs. He was told a replacement card would take two weeks to arrive.

"I don't have a really good outlook on the government," he said.

In Cincinnati, Renee Yankey, a government alcohol and tobacco tax specialist, was sleep-deprived after staying up late to watch news of the shutdown-ending deal, but otherwise glad to be back at work with the Alcohol and Tobacco Tax and Trade Bureau.

"I can tell that the alcohol industry missed us," Yankey said. "The first thing I hear is 'I'm so glad I got a person on the phone!'"

In North Little Rock, Ark, Simeon Yates was glad to return to work as an auditor for the Arkansas National Guard.

"It's definitely a relief financially ... knowing that we'll be able to provide for our families again," said Yates, whose wife stays home with their four young children.

"It was hard to explain to the kids," Yates added. "They enjoyed having me home, but when we were just having hot dogs a lot and pancakes ... you know, being small, they didn't necessarily understand that."

____

Associated Press writers Matthew Barakat in Reston, Va.; Ben Nuckols in Springfield, Va.; Dan Sewell in Cincinnati; Michael Rubinkam in Pottsville, Pa.; Jeannie Nuss in North Little Rock, Ark.; Kathy Matheson in Philadelphia; Rachel D'Oro in Anchorage, Alaska; and Jessica Gresko and Sam Hananel in Washington contributed to this report.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-10-17-Shutdown-Government%20Reopens/id-8471c28c58b64201aaae6f9dbfb65ffc
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Geography affects what drugs seniors prescribed

WASHINGTON (AP) — Where seniors live makes a difference not only in how much health care they receive but also the medications they're prescribed — as some miss out on key treatments while others get risky ones, new research shows.


More than 1 in 4 patients on Medicare's prescription drug plan filled at least one prescription for medications long deemed high-risk for seniors, according to the study released Tuesday by the Dartmouth Atlas Project.


Seniors who live in Alexandria, La., were more than three times as likely as those in Rochester, Minn., to receive those potentially harmful drugs, which include muscle relaxants and anxiety relievers that can cause excessive sedation, falls and other problems in older adults.


On the flip side, far more seniors who survived a heart attack were filling prescriptions for cholesterol-lowering statin drugs in Ogden, Utah, than in Abilene, Texas — 91 percent compared to just 44 percent, the study found. That's even though statins are proven to reduce those patients' risk of another heart attack.


Even more surprising, the study found just 14 percent of seniors who've broken a bone because of osteoporosis were receiving proven medications to guard against another fracture — ranging from 7 percent of those patients in Newark, N.J., to 28 percent in Honolulu.


"There's no good reason" for that variation, said lead researcher Dr. Jeffrey Munson, an assistant professor at the Dartmouth Institute for Health Policy and Clinical Practice.


Researchers with the Dartmouth Atlas have long shown that the type and amount of health care that people receive varies widely around the country, and that those who live where Medicare spends more don't get better quality care.


The newest report examined 2010 prescription data from the 37 million patients who get drug coverage under Medicare Part D, and found even more of a mixed picture when it comes to seniors' medications. For example, patients in the South were more likely to fill prescriptions for those riskier medications, but less likely than those in other regions to get the long-recommended treatments for heart and bone conditions.


The average Part D patient filled 49 monthlong prescriptions — either new ones or refills — in 2010.


But the study suggests doctors in some areas prescribe more readily. The highest number of prescriptions filled was in Miami — 63 — and the lowest in Grand Junction, Colo., 39.


Overall, patients in regions where Medicare Part D spent more on medications weren't more likely to receive the most effective medications, the study found.


Yes, seniors who are sicker will use more medications, but the general health of a region's Medicare population explains less than a third of the variation, the researchers concluded.


Patients don't always fill their prescriptions, because of cost or fear of side effects or myriad other reasons — something this study couldn't measure. It also didn't examine differences in benefits between cheaper and more expensive Part D plans.


But if doctors were following guidelines on best medication practices, there would be far less variation around the country, Munson said.


Doctors "really need to ask themselves, 'Is there a good reason why my patients are getting less effective care than patients in the other regions,'" he said.


He urged patients to ask more questions, too: Why is this medicine being prescribed? What are the pros and cons? Is there something else I should consider taking?


The Dartmouth Atlas, funded by the Robert Wood Johnson Foundation, studies health trends using Medicare data; similar figures aren't readily available for the general population.


___


Online:


Dartmouth Atlas: http://www.dartmouthatlas.org


Source: http://news.yahoo.com/geography-affects-drugs-seniors-prescribed-203205703--politics.html
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Saturday, October 19, 2013

Jon Bon Jovi Walks Super Fan Branka Delic Down the Aisle at Las Vegas Wedding: Picture


Jon Bon Jovi took another trip down the aisle this weekend! The New Jersey-born rocker, 51, made one fan's dreams come true on Saturday, Oct. 12, when he surprised her at her Las Vegas wedding to give her away.


The bride, 34-year-old Branka Delic of Australia, is such a huge Bon Jovi fan that she chose for her nuptials the same chapel where Bon Jovi married his high school sweetheart, Dorothea Hurley, back in 1989. She also started an online campaign (complete with a website and Facebook page) to get the music superstar to give her away to fiance Gonzalo "Gonzo" Cladera.


PHOTOS: Celebrity weddings in 2013


"All her life, Branka thought she would marry Bon Jovi himself. Sadly, at the age of 34 she realized this would never happen, and she accepted Gonzo's proposal instead," a statement on her website read. "She might not be marrying Bon Jovi, but the next best option is for her to walk down the same aisle he did 20 good strong years ago, so the stage has been set...The Graceland Chapel, Las Vegas, Nevada."


PHOTOS: Hollywood's hottest married couples


Coincidentally (or not), Bon Jovi had a concert at the MGM Grand in Las Vegas on the very same day that Delic and Cladera planned to tie the knot. "The only problem is, there's a real chance Branka will skip out on the wedding and go to the concert instead," her website read. "Gonzo has waited 14 years for this day, and if Branka skips it, he'll have to wait another 14."


PHOTOS: Famous wedding dresses from TV and film


Fortunately for all involved, Gonzo's wait is over. Bon Jovi stepped up and surprised the couple by showing up at the Graceland Chapel, where the rocker (a happily married father of four) walked Delic down the aisle and posed for pictures with the shocked bride.


"Congratulations, @branksd!" he tweeted after the ceremony. "May you & Gonzalo have a lifetime of happiness, love & memories together - ALWAYS!"


PHOTOS: The best wedding hairstyles


"Thanks, Jon," Delic replied. "You're an amazing human being for taking the time with us. See you in Sydney."


Later, on her Facebook page, she added: "I have memories for life which I'll never forget. Such an amazing man [to] take time from his schedule to come walk this crazy Aussie down the aisle...Jon...I salute! You're everything I ever imagined, an amazing and generous being...YOU MADE MY LIFE, BABY!!"


Source: http://www.usmagazine.com/celebrity-news/news/jon-bon-jovi-walks-super-fan-branka-delic-down-the-aisle-at-las-vegas-wedding-picture-20131410
Tags: Wally Bell   calvin johnson   broncos   nadal   Lady Gaga Vma  

For Chicago Mayor Rahm Emanuel, A Mixed Midterm Report Card





Former White House Chief of Staff Rahm Emanuel speaks at his election night party on Feb. 22, 2011, in Chicago. As mayor of Chicago, Emanuel has faced major challenges, ranging from a ballooning deficit to education, the economy and crime.



Kiichiro Sato/AP


Former White House Chief of Staff Rahm Emanuel speaks at his election night party on Feb. 22, 2011, in Chicago. As mayor of Chicago, Emanuel has faced major challenges, ranging from a ballooning deficit to education, the economy and crime.


Kiichiro Sato/AP


A little more than two years ago, Chicago's then-mayor-elect, Rahm Emanuel, expressed his gratitude to supporters on election night.


"Thank you Chicago, for this humbling victory," he told the crowd. "You sure know how to make a guy feel at home."


But today, Emanuel faces sobering challenges common to most of American's biggest cities.


Not only are schools troubled, Chicago's homicide rate spiked last year — a total of 516 murders — the highest in 10 years. Unemployment is 9 percent. And the city's deficit is looming near the $1 billion mark.


And that's just the short list of urgent problems.


Emanuel ran for mayor as a hometown boy, but he was never a part of the political dynasties that have defined Chicago. He'd left his position as White House chief of staff to govern a city controlled for more than 50 years by the Daley family. Richard J. Daley took office in 1955 and passed the power to a few Democratic protégés. Then his son, Richard M. Daley, served six terms before stepping aside in 2011.


The Daley dynasty was, ostensibly, over.


"And let's be honest, it's an impossible act to follow," Emanuel said on election night. "Yet, we have to move forward. And we know that we face serious new challenges."


'More An Operative Than A Manager'


Emanuel's new-guard Democratic credentials were solid: The three-term congressman had served five years as an adviser to the president in the Clinton White House, and then spent two years with President Obama as his chief of staff.


John Kass has been a reporter and columnist at the Chicago Tribune for more than 20 years. No fan of the Daleys, Kass has his doubts about Emanuel, who he says is more a creature of his Washington years than a genuine Chicagoan.





Members of the Chicago Teachers Union, parents, students and other opponents of a plan to close scores of Chicago public schools march through downtown Chicago in March. In the end, the city closed 50 schools, mostly in low-income communities.



Charles Rex Arbogast/AP


Members of the Chicago Teachers Union, parents, students and other opponents of a plan to close scores of Chicago public schools march through downtown Chicago in March. In the end, the city closed 50 schools, mostly in low-income communities.


Charles Rex Arbogast/AP


"He's trying to offer leadership in a very difficult situation," Kass says. "But he's actually more an operative than a manager. His problem is he's his own chief of staff. He's his own press secretary. You know, he's a control freak that way. He's just got to ... step back a little bit."


But, Kass concedes that Emanuel inherited a very troubled city, one that's running out of money.


"So in some sense Rahm is kind of like those lumberjacks that are on a log," he says. "They're rolling their feet ... to stay dry, because if you stop tapping, you'll fall in."


And, Kass says, part of what Emanuel inherited is a seemingly indestructible Democratic Party infrastructure that has outlasted the Daley dynasty, and still provides the framework for how Chicago works — or doesn't.


"This is a Democratic, blue state with Democratic bosses basically controlling it," Kass says. The Daley family controlled the city for half a century, while the Illinois state speaker of the House, Michael Madigan, has controlled the state legislature for about 30 years.


"They're both South Side Irish guys who know how to play," Kass says.


Chicago's Forgotten Victims


Kass says appreciating the context for Chicago's problems is critical, and the real story is often missed.


He says the murder of 15-year-old high school student Hadiya Pendleton in January hit the already suffering city like a cruel insult. The South Side teenager was shot to death while standing with friends in a park. Two weeks earlier, Pendleton performed at Obama's second inauguration.


The president spoke about Pendleton when he gave his State of the Union Address in February, two weeks after she was shot to death; the first lady, Michelle Obama, attended Pendleton's funeral in Chicago.


"She was what I called the perfect victim — young, innocent, people identified with her. She became symbolic," Kass says.


"Unfortunately, in Chicago, there are what I call imperfect victims. ... Every day there are kids like Nazia Banks and other little young boys that I've written about and he falls through the media cracks, he's not beloved or made into an icon for political purposes. He's just forgotten."


The City's Unheard Voices


The real story of Chicago is nuanced — and evaluations of the mayor's tenure vary accordingly.


Laura Washington, a longtime Chicago political analyst and Chicago Sun-Times columnist, says people ask her all the time how the Emanuel administration is doing so far.





Protesters at an anti-gun violence rally in Chicago in February hold up photos of 15-year-old Hadiya Pendleton at the scene where she was killed Jan. 29. She was shot dead two weeks after she performed at President Obama's second inauguration.



Charles Rex Arbogast/AP


Protesters at an anti-gun violence rally in Chicago in February hold up photos of 15-year-old Hadiya Pendleton at the scene where she was killed Jan. 29. She was shot dead two weeks after she performed at President Obama's second inauguration.


Charles Rex Arbogast/AP


"My answer is, you have to ask how Chicago is doing and you have to decide which Chicago you want to ask," she tells NPR's Arun Rath.


For instance, she says, downtown corporate power brokers are very happy with the city's direction.


"But there's another Chicago, and that tends to be among communities of color, that feel their voices have not been heard," Washington says.


Chicagoans appreciate Emanuel's trademark aggressive style, Washington says, but he's not a natural negotiator.


"We love a good fight in Chicago, and we like to get down and dirty," Washington says. "I think that the problem is that he doesn't leave room for dissension, and he doesn't tolerate backtalk."


School Closures, Clashes With Unions


A major controversy was his decision to close 50 schools to help balance the budget.


"The schools were closed in areas that had lost significant population over the last 10 years ... most of them in communities of color, low-income communities," Washington says. "Folks representing those communities — from the teachers to the parents to the students — felt betrayed."


The union issues haven't ended there: Washington says the mayor has picked fights with the police and firefighters unions.


"He's perceived as being a very much pro-corporate, very much pro-privatization, so that has made folks, especially in the union community, very, very hostile to him," she says.


Nonetheless, Washington says she thinks Chicagoans got what they expected — a tough, single-minded, controlling mayor — but they're disappointed that change hasn't come as quickly as they'd like.


"The violence thing is very disturbing I think to a lot of folks, because there's no clear, obvious reasons why Chicago's violence feels so out of control," she says.


Neglect Of Environmental Issues


The problems in Chicago are big enough and stubborn enough that some significant issues linger on the margins of the mayor's agenda.


Lake Michigan and the Chicago River are polluted, and the city faces many energy and environmental justice issues.


But shortly after Emanuel took office, he dismantled the city's Department of Environment, citing budget constraints. Some staffers were cut, while others were moved to different city departments.


Henry Henderson, the Midwest director for the Natural Resources Defense Council, was Chicago's commissioner of the environment under Mayor Richard M. Daley from 1991 until 1998.


Henderson says Emanuel doesn't see the environment as an organizing principle.


"There is a problem of how it fits within a vision of the future of the city," Henderson says. "Clearly, fiscal responsibility, economic development, significant problems with schools and violence are pervasive. How to integrate energy, water quality, air quality within a central part of the initiatives of the city, remain questions."


Tough To Beat


But the biggest question of all is whether Emanuel will try for a second term.


With no significant challengers so far, he has reportedly already raised $5 million for a re-election campaign.


That's a lot of money, but the election is still more than a year away, says Washington, the Chicago Sun-Times columnist. She expects him to triple that amount by election time in 2015.


"I think he's looking really tough to beat right now," she says.


Washington says the mixed results on the issues, and mixed reviews from Chicagoans, don't mean Emanuel can't win a second term — if he wants it.


"One of the things that I think disturbs some voters here is that they feel that Rahm Emanuel's always got one foot in and one foot out," she says. "Some people think he has presidential aspirations, which he's denied repeatedly, but I think people are a little bit wary of whether he's going to be around for the long haul."


Source: http://www.npr.org/2013/10/19/237792692/for-chicago-mayor-rahm-emanuel-a-rough-midterm-report-card?ft=1&f=1001
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Primary fault (Unqualified Offerings)

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Seene Uses Computer Vision To Create Unique And Eerie 3D Images On iPhone


It’s not often that I use a new ‘photo capture’ app and impressed by it within seconds. It’s not that there’s not a lot of cool stuff being built out there, it’s just that the frontiers are getting closer and easier to predict.


That’s not true with Seene, an app by computer vision company Obvious Engineering that leverages smartphone sensors and WebGL to present curious and eerie 3D scenes. The app is the product of four-man team including CEO Andrew McPhee and CTO Sam Hare. The ‘seenes’ themselves are images mapped onto a rough 3D model of your subject that give the feeling of being able to shift perspective even after you’ve shot it.


This produces small three-dimensional digital dioramas of a moment in time and space.


The capture process is simple. You tap on the capture button to shoot an image and then turn your device to capture the sides, top and bottom of your subject. Just a few degrees will do. The image is then processed and mapped onto a simple object that approximates 3D space. You can then view it in 3D or share it with others.



There are a couple of interesting components to Seene, in my view. First, it has the same sort of post-capture feel that Lytro, the focus-stacking camera that everyone loves but that has failed to gain an immense amount of traction in its current hardware form. The power of that kind of experience is interesting in the way that it ‘explodes’ these static images out into things that approximate human vision. In the case of Lytro it’s the way that our eyes nearly instantly re-focus when they travel from object to object. With Seene, it’s our simple but compelling binocular vision that creates a feeling of ‘being there’.


Seene is also an experience that couldn’t exist in the way that it does without the smartphone, something it has in common with other interesting services like FrontBack and Vine. You couldn’t capture a Seene without a mobile camera in your pocket attached to accelerometers and a powerful dual-core processor that renders the images. The only mass-produced product like this that’s ever been made is the smartphone.



The processing power required is one reason that only iPhone 4S and newer devices can create Seenes, though most other devices can view them.


There have been plenty of other experiments using computer vision to model 3D scenes on the web, but Seene doesn’t use cloud processing to accomplish the unique images it produces. Instead everything, from capture to mapping to processing is done right on the device. And the processing time is nearly instantaneous, a fully rendered Seene pops up almost immediately after shooting on new devices like the iPhone 5s.


Obvious Engineering was founded in March of 2012 and typically works on projects for clients using their computer vision expertise. Seene, says McPhee came out of a desire of the team to build “something that was our idea.”


“Photos drive social communication,” McPhee says and that made them want to do something on a ‘mass scale’ that had the potential to reach hundreds of millions of users. It’s the first thing they’ve attempted to do on this scale.



The experience of viewing a Seene in the hand is fairly visceral, as tilting your hand or body will move the 3D image around as if you were ‘looking around the corner’ of an image. I’ve experienced the desire to do that with really compelling images before, but this is the first time I’ve been able to do it and the effect has really impressed me.


You can also view Seenes in browsers that are WebGL compatible like Chrome and new versions of Safari.


Hare says they’ve had testers in London like directors and photographers producing compelling material that ‘feels’ like a photograph but do things with the app that they hadn’t foreseen. McPhee says that these results come from users who have “different ways of looking at the world.”


And indeed some of the Seenes out there are pretty clever, though it does take a bit of experimentation to get results that look great. In my experience, the best subjects are shot at a medium distance, not close up. Moving subjects aren’t really an option at this point though an image of a fountain I shot did give off the impression that water droplets were hovering in mid-air, very cool.


The team is bootstrapped currently but looking for funding. I’m not sure what kind of future an app like Seene has at scale without the welcoming arms of a larger entity. But the initial experience is fairly compelling.


The dangers here, of course, is that there are all sorts of compelling silos and feeds out there vying for our attention. Instagram, Vine, FrontBack and more all create vertical streams of cool, clever things. But there are only so many hours in the day. Is Seene compelling enough to slice off a chunk of that time?


If it gets enough traction and people take to the unique ‘seenes’ that it presents, there could be something here. I hope so, because the team says that they have a bunch of ideas for how to make the app better and some cool features that they need resources to execute, and so far I’m intrigued.


You can grab Seene on the App Store here.



Source: http://feedproxy.google.com/~r/Techcrunch/~3/6O2N0WllrTs/
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Joan Ganz Cooney, Co-Founder Of Sesame Workshop



Jessica Harris speaks with television producer Joan Ganz Cooney, co-founder of Sesame Workshop, a non-profit organization that develops children's shows intended to help children everywhere reach their highest potential. After, she talks with Stephen McDonnell, founder of Applegate Farms, a natural organic meat company.


Source: http://www.npr.org/2013/10/17/236306448/joan-ganz-cooney-co-founder-of-sesame-workshop?ft=1&f=
Category: elizabeth smart   world war z   msft   Lucas Cruikshank   Mackenzie Rosman  

Suicide truck bomber kills 15 in northern Iraq


MOSUL, Iraq (Reuters) - A suicide bomber driving a truck packed with explosives blew himself up in a village in northern Iraq, killing at least 15 members of the country's Shabak minority early on Thursday, police said.


It was not immediately clear who was behind the attack, but Sunni Islamist militants have in the past targeted Shabaks, who are predominantly Shi'ite, and warned them to leave the area.


The attack took place in the village of Mwafaqiya in Nineveh province.


"At 6 am this morning, a suicide truck bomber detonated himself amidst the houses of my village," said Qusay Abbas, a former Shabak representative in the Mousl provincial council. "There are still some people under the debris of their houses".


Sunni Islamist and other insurgents including an al Qaeda affiliate have been regaining ground this year in an onslaught against Iraq's Shi'ite-led government and its allies.


Al Qaeda views Shi'ite Muslims as non-believers.


More than 6,000 people have been killed in acts of violence across the country this year, according to monitoring group Iraq Body Count.


Last month, a suicide bomb attack on a Shabak funeral in Nineveh killed 21 people.


(Reporting by Ziad al-Sinjary; Writing by Raheem Salman; Editing by John Stonestreet)



Source: http://news.yahoo.com/suicide-truck-bomber-kills-11-northern-iraq-police-064754798.html
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U.S. FDA panel backs Paladin Labs' parasitic disease drug


By Toni Clarke


(Reuters) - Paladin Labs Inc's experimental drug to treat a rare parasitic disease is effective and safe enough to be approved, an advisory panel to the U.S. Food and Drug Administration said on Friday.


The drug, Impavido, is designed to treat three forms of leishmaniasis, a disease caused by a group of parasites known as Leishmania, which are spread by the bite of a female sand fly.


The FDA is not bound to follow its advisory panel's advice but typically does so.


Impavido was granted priority review by the FDA, a status that cuts the review time to six months from the standard 10. Priority review is typically given to experimental products that address an unmet medical need or represent a major advance over current treatments.


If Impavido is approved, Paladin, which is based in Montreal, Canada, would receive a voucher from the FDA giving it the right to receive a priority review of future product that might not otherwise qualify for such a review.


Such vouchers, designed to encourage development of new treatments for tropical diseases, can be sold to another company.


Leishmaniasis comes in several forms: cutaneous, which causes sores and ulcers on the skin; visceral, which affects internal organs such as the spleen, liver and bone marrow; and mucosal, which can cause disabling sores in the nose, mouth and throat.


The disease affects an estimated 12 million people globally, according to the World Health Organization, with an estimated 1 million-2 million new cases occurring each year.


The drug, also known as miltefosine, is currently listed as one of five therapies for the disease on the WHO's Essential Medicines list. It is currently approved in Europe, the Indian subcontinent, and Central and South America.


Leishmaniasis is found most often in the tropics, subtropics and southern Europe. In the United States people most at risk include those immigrating or traveling from countries where the disease is prevalent, military personnel and people with compromised immune systems.


The panel voted 14-2 to approve the drug for cutaneous leishmaniasis, the most common form. It voted 15-1 in favor for visceral leishmaniasis, the most severe form; and it voted 13-3 in favor for mucosal disease.


The FDA is due to rule by December 19 on whether to approve the drug.


(Reporting by Toni Clarke in Washington; Editing by Gerald E. McCormick and Jim Marshall)



Source: http://news.yahoo.com/u-fda-panel-backs-paladin-labs-parasitic-disease-185035312--finance.html
Tags: Ken Norton   world war z   Nokia   Outside Lands   Aaron Paul  

Friday, October 18, 2013

'Avatar' Sequels to Begin Production in October 2014



We're just a year away from the start of production on the second in James Cameron's Avatar movie series, according to its lead actor, with the director currently hard at work "building the ship to Pandora." Hopefully, he means that in the metaphorical sense.



Talking during an interview with Australian radio station Nova 96.9, Sam Worthington said that he expected photography to begin on Avatar 2 in October 2014, with shooting for the second, third and fourth movies in the series to be completed within a year ahead of each new installment's annual release, from December 2016 through December 2018.


STORY: James Cameron Brings in Writer Josh Friedman for 'Avatar 2' Script


It's almost been four years since the release of the first Avatar, and just two months since it was revealed that Cameron would create three sequels instead of the originally planned two, with Josh Friedman, Rick Jaffa, Amanda Silver and Shane Salerno writing the screenplays. Additionally, novelist Steven Gould has been signed to write four original novels to support the new series.



Source: http://feedproxy.google.com/~r/thr/film/~3/GX03GxMKxEE/story01.htm
Category: scarlett johansson   carrie underwood   Tom Harmon   Nsync Vma   Hasnat Khan  

A Fight Over Vineyards Pits Redwoods Against Red Wine





Environmental groups are fighting to stop the leveling of 154 acres of coastal redwoods and Douglas firs to make way for grapevines.



Courtesy Friends of the Gualala River


Environmental groups are fighting to stop the leveling of 154 acres of coastal redwoods and Douglas firs to make way for grapevines.


Courtesy Friends of the Gualala River


In the California wine mecca of Sonoma County, climate change is pitting redwood lovers against red wine lovers.


This Friday morning, a coalition of environmental groups are in a Santa Rosa, Calif., courtroom fighting to stop a Spanish-owned winery from leveling 154 acres of coast redwoods and Douglas firs to make way for grapevines.


Redwoods only grow in the relatively cool coastal region of Northern California and southern Oregon. Parts of this range, such as northwestern Sonoma County, have become increasingly coveted by winemakers.


Chris Poehlmann, president of a small organization called Friends of the Gualala River, says the wine industry is creeping toward the coast as California's interior valleys heat up and as consumers show preferences for cooler-weather grapes like pinot noir.


"Inexorably, the wine industry is looking for new places to plant vineyards," says Poehlmann, whose group is among the plaintiffs.


California's Department of Forestry and Fire Protection, or CalFire, approved the redwood-clearing project in May 2012.


"So we sued them," says Dave Jordan, the legal liaison for the Sierra Club's Redwood Chapter, another of the plaintiffs. The Center for Biological Diversity is the third plaintiff.


The groups filed suit in June 2012 on the grounds that state officials violated California's environmental protection laws by approving the plan.


Redwoods are considered among the most spectacular of all trees. The biggest trees on Earth by height, redwoods can stand more than 350 feet tall. Some are more than 2,000 years old.


However, the redwoods at the center of this conflict are not old-growth trees. The area was clear-cut more than 50 years ago, and most of the redwoods on the site are less than 100 feet tall. Which is why Sam Singer argues: "There are no forests [on this site]."


Singer is a spokesman for Artesa Vineyards and Winery, which is owned by the Spanish Codorniu Group and which first proposed the development project in 2001. Singer says that the two old-growth redwood trees on the property will be spared.


But the thousands of trees slated for removal are between 50 and 80 feet tall, according to Poehlmann. He says the trees provide wildlife habitat and stabilize the soil against erosion, which has been a major problem for streams in the area that once harbored runs of salmon and steelhead trout.





Coast redwood trees stand at Muir Woods National Monument in Mill Valley, Calif. Redwoods are the biggest trees on Earth by height — they can grow more than 350 feet tall. But their range is quite limited: They only grow along the coast of Northern California and southern Oregon.



Justin Sullivan/Getty Images


Coast redwood trees stand at Muir Woods National Monument in Mill Valley, Calif. Redwoods are the biggest trees on Earth by height — they can grow more than 350 feet tall. But their range is quite limited: They only grow along the coast of Northern California and southern Oregon.


Justin Sullivan/Getty Images


The project planners have even estimated this timber to represent 1.25 million board feet of "merchantable" lumber.


Dennis Hall, a higher official with CalFire, says his department's approval of Artesa's project in 2012 came only after a lengthy review process found that it would not significantly damage the environment.


"We did an [environmental impact report] for the project," Hall says. "It was an extreme and exhaustive analysis of potential impacts to the environment." The report deemed most of these potential impacts to be "less-than-significant."


Still, Poehlmann feels CalFire has been too lenient on proposals by developers to level trees. "They are acting as if they are actually the 'department of deforestation," he says.


The tensions go beyond this case: Friends of the Gualala River and the Sierra Club's Redwood Chapter have gone to court several times in the past decade to successfully stop timberland conversion projects proposed by winery groups and which had been approved by the state. Among these fights was the battle to save the so-called Preservation Ranch, a 19,000-acre parcel that developers planned to partially deforest and replant with vines. Earlier this year, the developer sold the property to The Conservation Fund.


But from 1979 to 2006, 25 conversions of forest to agriculture occurred in Sonoma County at an average rate of 21 acres per year, according to county officials.


At least a few tree clearing projects have occurred without permission. High-profile winemaker Paul Hobbs didn't bother getting a permit before he leveled eight acres of redwoods in 2011 with plans to plant wine grapes. He remains a superstar winemaker and was tagged earlier this year by Forbes as "The Steve Jobs of Wine."


And it's not just redwoods that are at stake as vineyards expand their terrain. California's oaks aren't subject to the same environmental protections as more commercially valuable species like redwoods and Douglas fir, according to CalFire's Hall. And Northern California's oak forest, near the coast as well as inland, is being lost at fast rates to vineyard expansions, says Adina Merenlender, an environmental biologist with U.C. Berkeley.


Merenlender says oak trees tend to be overlooked by the general public, which is more easily impressed by redwoods. Yet oak forests, she says, provide habitat for vastly more species than do redwood forests.


Sara Cummings with the Sonoma Vintners, a wine industry trade group, says new vineyards are usually planted within what she calls the region's "agricultural footprint"—land that is already designated by county planners as "agricultural." Moreover, she says, more than half the county's winegrowers are members of the California Sustainable Winegrowing Program.


But Merenlender is concerned about future expansion into land not previously farmed.


"We're already seeing a lot of acquisition of coastal lands," she says. "Investments are moving north and west, toward the coast."


The issue, it seems, is a global one. A 2013 study predicted that global warming will cause a dramatic shift in the world's wine regions. The report warns that wilderness areas in British Columbia and remote regions of China—one of the world's fastest-growing winemaking regions—may become increasingly coveted by the industry.


"But at least we'll have plenty of wine to drink, "Poehlmann quips, "while we bemoan the fact that our forests are all used up."


Source: http://www.npr.org/blogs/thesalt/2013/10/18/237136077/a-fight-over-vineyards-pits-redwoods-against-red-wine?ft=1&f=1008
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Google stock crosses $1,000 mark after earnings

NEW YORK (AP) — Strong third-quarter results have sent Google shares past the $1,000 mark for the first time.

Shortly after the markets opened Friday, Google Inc. shares jumped more than 12 percent to $1,002. The stock had never before surpassed $928 in regular market trading since Google went public at $85 per share nine years ago.

Late Thursday, Google reported better-than-expected third-quarter results. The numbers showed that while the company's advertising prices continue to decline, that's being offset by a larger number of people clicking on ads.

Google shares have climbed steadily for much of the past five years, more than doubling in value. But the stock has slipped slightly in recent months, while the overall market has risen, amid worries about deteriorating ad prices.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-10-18-Google-$1000%20Stock/id-2b58c71d2a0e4dda8247c2ad582a9750
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‘Minotauro’ on Palhares: ‘He has never thought of doing anything evil to any opponent’


Jason Silva-USA TODAY Sports



Rousimar Palhares is finally receiving some support during the worst week of his career.


Released from the UFC after a controversial submission win over Mike Pierce at UFC Fight Night 29, "Toquinho" heard several promotions deny the possibility of hiring him even before he tries to make contact, and the leaders of his team decided to defend him.


"I can say that in our gym, ‘Toquinho’ has never hurt anyone," Rodrigo "Minotauro" Nogueira, the leader of Team Nogueira in Rio de Janeiro, stated in a release sent to MMAFighting.com. "He is a good person, excellent company and a man with a great character. I believe that he has never thought of doing anything evil to any opponent because this isn’t his conduct.


"I don’t question UFC’s decision because the people who are in control have a global view of the business and they understand it better than anyone in the whole business that involves our sport."


UFC president Dana White said that what Palhares’ did "was wrong and really despicable", and that’s why he decided to release him. The Brazilian, who was already suspended in the past for holding a submission too long, was suspended for 120 days by the Brazilian Athletic Comission (CABMMA) following his 31-second win at UFN 29.


"Minotauro", a jiu-jitsu expect with 21 submission victories, has never finished a fight with ankle locks or heel hooks, but he says the fighter needs to be "explosive" to get the win with attacks like these.


"It’s a dangerous position and the guy who applies it has to be explosive," he said. "At the time, you don’t look at the opponent. ‘Toquinho’ lost the position several times because he released the grip a little. It’s a position that you go with everything or you lose it. It’s a complicated situation. The referee needs to be aware and has to intervene in an energetic way."


Rogerio "Minotouro" Nogueira, "Minotauro’s" twin brother, defended his teammate as well.


"I've known Rousimar for years," "Minotouro" said. "As an athlete he’s a phenom, and as a person he’s loved by everyone, especially for his simplicity. Anyone who knows the history of his life will be enchanted with his modesty and dedication to the sport. ‘Toquinho’ was always the first to arrive and the last to leave the gym, always a great help to our athletes, and we’re sure he will continue to do so because Team Nogueira will always be by his side."


Source: http://www.mmafighting.com/2013/10/17/4847990/rodrigo-nogueira-rousimar-palhares-ufc-fight-night-29-mma-news
Category: Prisoners   christina aguilera   Nick Pasquale   Tropical Storm Flossie   queen elizabeth  

HTC One Max review

The debate around giant smartphones is over. Manufacturers like Samsung, Sony and LG have amply demonstrated that it's possible to build a pocketable, phone-like device with a screen bigger than five inches. Now it's HTC's turn. But instead of re-imagining the much-praised One for this new category ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/pkn782hxBRs/
Tags: Monika Jakisic   Cloudy With A Chance Of Meatballs 2   Navy Yard shooting   rosh hashanah   Jason Dufner  

Grilosodes Ep. 5: Style Sessions and Dry Slopes



Posted by: Evan Litsios / added: 10.17.2013 / Back to What Up


This episode of Grilosodes follows Marco Grilc to Nicolas Muller's Style Session in Zurich, where he sends some areals alongside Eero Ettala and a bunch of dirt bikers. After the contest he shreds Austria for a minute, but when conditions go sour he flies up to England to check out what it's like to snowboard on plastic instead of snow. 






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Source: http://www.frqncy.com/news/2013/10/17/grilosodes-ep-5-style-sessions-and-dry-slopes?utm_campaign=blog_feed&utm_medium=feed&utm_source=feed_reader
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Thursday, October 17, 2013

Verizon Droid Mini, Ultra and Maxx all receive price cuts

Motorola Droid Ultra and Maxx

Savings of $50 or $100 both on and off contract at the online store

Coming around on three months since their release, Verizon has just cut the prices of its latest lineup of Droid devices from Motorola. If you head over to the Verizon online store today you'll find that Droid Maxx on sale for $199, Droid Ultra for $99 and Droid Mini for $49 — that's a cut of $100 for the Maxx and Ultra, and $50 for the Mini. It looks as though the off-contract prices have dropped as well, hitting $499, $449 and $399, respectively.

We're not entirely sure what the reasoning is behind a price drop just three months after going on sale, but if you've been holding off on picking up one of the new Droid devices now may be the time. We're seeing the price drops on the web without any special actions, but we can't say whether or not you'll find these deals in retail stores.

More: Motorola Droid Ultra review

Source: Verizon (Maxx); (Ultra); (Mini); Thanks, Saumil!


    






Source: http://feedproxy.google.com/~r/androidcentral/~3/wD5PTbejolU/story01.htm
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Experts Debate How Best To Remove Syria's Chemical Weapons


Secretary of State John Kerry says he's hoping Syria's chemical weapons stockpiles can be consolidated quickly and shipped out of the country. Experts say it is possible, but risky. International chemical weapons experts are still mapping out Syria's stockpiles to see what can be moved.



Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


RENEE MONTAGNE, HOST:


This is MORNING EDITION, from NPR News. I'm Renee Montagne.


Let's go deeper now into one issue Secretary of State John Kerry raised in my interview with him earlier in the program. The secretary, along with his Russian counterpart, got Syria's Bashar al-Assad to agree to hand over his vast store of chemical weapons. Now, Kerry is suggesting those stockpiles be taken out of Syria.


SECRETARY JOHN KERRY: We know the locations. Locations have been declared. Locations are being secured. And my hope is that much of this material will be moved as rapidly possible into one location and - hopefully on a ship - and removed from the region.


MONTAGNE: Where that ship might go is an open question, and experts are still debating what's feasible inside Syria, as NPR's Michele Kelemen reports.


MICHELE KELEMEN, BYLINE: The Nobel Peace Prize-winning Organization for the Prohibition of Chemical Weapons is mapping out Syria's chemical weapons program, taking stock of what Syria has and deciding how best to destroy it all by the middle of next year. U.N. Secretary-General Ban Ki-moon has tapped Sigrid Kaag, a Dutch U.N. expert, to oversee this unprecedented mission.


(SOUNDBITE OF SPEECH)


BAN KI-MOON: The situation in Syria remains dangerous and unpredictable. The cooperation of all parties in Syria is required.


KELEMEN: The chemical weapons convention bars countries from moving their stockpiles. But in Syria's case, a U.N. resolution allows it, and urges member states to help. So Ralf Trapp, a former OPCW expert, says the idea of shipping out the stockpiles has been under discussion, though he says the logistics are tough.


RALF TRAPP: Just doing this under normal peacetime conditions is not an easy option. So doing it under the conditions of the Syria of today, it's a challenge.


KELEMEN: Trapp says most of Syria's chemical stockpiles are stored in bulk, and as precursors. So other countries could help to destroy that material if it can be safely transported.


TRAPP: The precursor chemicals are not as much of a problem, because they are more or less in the same category as other types of industrial chemicals. So destroying them is something many countries with the right chemical infrastructure could do.


KELEMEN: But there are only a few countries, he says, that have the facilities to destroy chemical warfare agents. The U.S., for instance, has developed a portable hydrolysis unit it could offer, according to Amy Smithson, who's with the James Martin Center for Nonproliferation Studies at the Monterey Institute.


AMY SMITHSON: This is a unit that uses literally hot water and other chemicals to degrade chemical warfare agents and chemical precursors, eliminating over 99 percent of the toxicity of the chemicals.


KELEMEN: Step one, though, is just consolidating Syria's chemical warfare agents, now spread out in more than 20 sites across the country. And that's tricky, Smithson says, under any circumstances.


SMITHSON: Chemicals tend to be very corrosive, particularly the chemicals that are used to make chemical warfare agents. And if this stuff has been sitting in munitions or in bulk storage containers for a considerable amount of time, there may be considerable safety risks to move that.


KELEMEN: She says the U.S. has experience moving its stockpiles from Europe to an atoll in the Pacific in the 1980s. And Russia moved some of its chemical weapons out of Eastern Europe after the collapse of the Soviet Union. So there are precedents, just not in the midst of a civil war.


Michele Kelemen, NPR News, Washington.


Copyright © 2013 NPR. All rights reserved. No quotes from the materials contained herein may be used in any media without attribution to NPR. This transcript is provided for personal, noncommercial use only, pursuant to our Terms of Use. Any other use requires NPR's prior permission. Visit our permissions page for further information.


NPR transcripts are created on a rush deadline by a contractor for NPR, and accuracy and availability may vary. This text may not be in its final form and may be updated or revised in the future. Please be aware that the authoritative record of NPR's programming is the audio.


Source: http://www.npr.org/2013/10/17/235981350/experts-debate-how-best-to-remove-syrias-chemical-weapons?ft=1&f=1009
Category: iPhone 5S   apple event   Miley Cyrus Vmas 2013   true blood   Sonic  

Pop’s Lamest Lyric

Miley Cyrus
Miley Cyrus is a perpetrator of music's most nonsensical lyric. But she's not alone.

Photo silhouette by Slate. Photo by Fred Prouser/Reuters








Even before Miley Cyrus’ chart-topping album Bangerz was released last week, devotees were already poring over the leaked lyrics, searching for clues as to how she was coping without former beau Liam Hemsworth. Sure enough, buried amid the Auto-Tuned swoons of “My Darlin' ” was a line that seemed to tell it all: “I can’t breathe without you, without you as mine.”














Either recording booths in the 21st century need to come equipped with oxygen masks, or today’s lyricists tend to brood over their breakups in the intensive care unit. Presenting an inability to breathe has become a ubiquitous songwriting crutch, an insipid shorthand to express longing or describe an emotional trauma. It’s my candidate for the laziest lyric of the century.










The instant the line is uttered, the fallacy is exposed, and the moment deflates.










This particular pet peeve first colonized my brain when I caught the chorus to Taylor Swift’s 2008 ballad “Breathe”: “And I can’t breathe without you, but I have to.” It’s true, you do! Suddenly, whenever a top 40 radio station hit the dial, the proclamations of asphyxiations came fast and steady, and I began amassing a “can’t breathe” case file. True, the same could be said of familiar tropes like tacking on that a scene is transpiring in the rain to make the setting more urgent or melancholy, or that yes, you own the night. And where would all the Mumford-style bands be without all that blood they bleed? But I contend there’s something uniquely irritating about “can’t breathe.”












What I find so odd about this particular lazy metaphor is that the act of singing the lyric disproves its intent. Writer’s block yields piles of unused paper. Painters in a rut neglect their canvases. But a singer is actually using the air in his or her heartsick lungs to express, and then dispel, this thoroughly exhausted announcement of breathlessness. The instant the line is uttered, the fallacy is exposed, and the moment deflates.










On “Jealousy,” Will Young drops to his knees when he feels like he can’t breathe. Leona Lewis, a winner on The X Factor, sings the eponymous lyric dozens of times in “Can’t Breathe,” but at least acknowledges that this separation of soul mate and oxygen supply spells doom (note the shout-outs to getting weak and feeling like death is close). Michelle Branch is less dramatic; she limits her bated breath to counts of 10. Tom DeLonge of Angels & Airwaves gave the expression a slight twist with his emo inflection, ratcheting the annoyance factor to unseen heights.










How is it that a set piece as emotionally charged and relatable as withdrawing to dress your wounds after a breakup has funneled down to the “can’t breathe” trope? Consider the lyrical complexities of a standard like “Hello Walls,” written by Willie Nelson in 1961, in which the despondent crooner resorts to conversations with inanimate objects while holed up in his bedroom, asking the window if that’s rain or a teardrop streaking down the pane. Now there’s an image fully rendered. A contemporary ballad like Frank Ocean’s “Pyramids” also finds a man wallowing in a vacant room, wondering where his partner spends her nights, but the lyrical composition benefits from a wide scope backed by hyperspecific details, opening in the age of hieroglyphs before descending into VCR snow.










Perhaps the clearest explanation for how we arrived at this “can’t breathe” cul-de-sac can be found in John Seabrook’s recent New Yorker profile of Lukasz Gottwald. Gottwald, also known as Dr. Luke, is the 40-year-old hit-maker who came to worldwide prominence in 2004 after co-writing Kelly Clarkson’s “Since U Been Gone,” the power-pop anthem capped by the chorus “Since you been gone, I can breathe for the first time.” (Clarkson, it should be noted, is a multiple offender; in “Addicted,” she sings that she “can’t breathe” after a “leech” of an ex sucks the life from her.) Gottwald tells Seabrook he’s never finished a book, and that he finds lyric writing “not fun,” preferring to farm out that responsibility to lyricists like Bonnie McKee, who explains to Seabrook that the process is “very mathematical. A line has to have a certain number of syllables, and the next line has to be its mirror image.” In this paradigm, it’s understandable that familiar lyrics get slotted into well-trod emotional cues. The formula is certainly a winning one; Gottwald has had a hand in “as many No. 1s in 2010 as the Beatles had in any single year.”










Perhaps this phenomenon of syllables over substance isn’t quite so toxic. What I find the most virtuosic vocal performance of the year, the guest verses by Bone Thugs-n-Harmony on the ASAP Ferg track “Lord,” is a monument to syllable-by-syllable construction. And when it comes to writers resorting to the can’t-breathe crutch, few of us are immune. After stumbling out of a screening of Gravity earlier this month, like countless other thoroughly satisfied, shell-shocked film critics I retreated to my laptop, declaring the film to be “breathtaking.”










With that off my chest, I can breathe for the first time.








Source: http://www.slate.com/articles/arts/culturebox/2013/10/miley_cyrus_taylor_swift_kelly_clarkson_they_ve_all_used_a_version_of_songwriting.html
Category: nhl   Dylan Penn   Pretty Little Liars   Marion Bartoli   Jason Dufner  

Researchers discover new approach to improve personalized cancer treatments

Researchers discover new approach to improve personalized cancer treatments


[ Back to EurekAlert! ]
Public release date: 14-Oct-2013
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Contact: Rhonda Zurn
rzurn@umn.edu
612-626-7959
University of Minnesota



Computer scientists worked with doctors to develop new treatment that would kill cancer cells but spare healthy cells



Researchers from the University of Minnesota, Mayo Clinic, and University of Toronto have successfully shown that a new method for targeting mutated cells could create a major breakthrough in a personalized medicine approach to treat cancer.


The team's findings are published in the Oct. 15 issue of Cancer Research, a journal of the American Association of Cancer Research.


The new research discovers susceptible genes in the cancer cells using synthetic lethal interactionspairs of genes in which mutation in either gene alone causes no damage to the cell, but where mutations in both cause the death of the cell.


"When we discover these interactions in human cells, it can hold the key to effective, targeted cancer treatments," said Professor Chad Myers, the lead researcher and computer science and engineering associate professor in the University of Minnesota's College of Science and Engineering. "Specifically, drugs could be used to target the synthetic lethal interaction partners of cancer-associated genetic mutations. These drugs would then effectively kill cancer cells but spare otherwise identical cells lacking the cancer-related genetic alteration."


Myers and his collaborators used research on yeast genes to find synthetic lethality, and then found genes in humans that were similar in structure and evolutionary origin to the yeast cells. Myers worked with Dr. Dennis Wigle, a practicing thoracic surgical oncologist at Mayo Clinic to test those interactions in human cells.


They found two striking cases where synthetic lethal interactions were similar between yeast and human cells. These interactions involve genes that are frequently mutated in specific types of cancer and provide potential new drug targets for these tumors.


"About 40 percent of yeast genes have homologs in humans, we thought that inferring interactions across species may provide a quick way of getting at these interactions," Myers said. "Given our expertise with the yeast interactions, we developed a strategy for narrowing down the large list of interactions to test, based on sequence similarity between the genes and public databases of genes commonly mutated in cancer as well as other features."


Decades of drug discovery research have produced a limited number of targeted therapies for treating cancer. The most commonly used therapies involve delivering high doses of radiation or toxic chemicals to the patient, which can help to suppress tumor growth but also cause substantial damage to normal tissue.


"The strategy of using synthetic lethal interactions to identify drug targets, particularly for 'undruggable' cancer genes is an attractive alternative method for drug target discovery," said Wigle. "This technology is an important means to fully leverage information from sequencing projects for clinical application."


###


To read the full research paper entitled "A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer," visit http://cancerres.aacrjournals.org/content/early/2013/10/04/0008-5472.CAN-12-3956.abstract.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Researchers discover new approach to improve personalized cancer treatments


[ Back to EurekAlert! ]
Public release date: 14-Oct-2013
[


| E-mail



| Share Share

]

Contact: Rhonda Zurn
rzurn@umn.edu
612-626-7959
University of Minnesota



Computer scientists worked with doctors to develop new treatment that would kill cancer cells but spare healthy cells



Researchers from the University of Minnesota, Mayo Clinic, and University of Toronto have successfully shown that a new method for targeting mutated cells could create a major breakthrough in a personalized medicine approach to treat cancer.


The team's findings are published in the Oct. 15 issue of Cancer Research, a journal of the American Association of Cancer Research.


The new research discovers susceptible genes in the cancer cells using synthetic lethal interactionspairs of genes in which mutation in either gene alone causes no damage to the cell, but where mutations in both cause the death of the cell.


"When we discover these interactions in human cells, it can hold the key to effective, targeted cancer treatments," said Professor Chad Myers, the lead researcher and computer science and engineering associate professor in the University of Minnesota's College of Science and Engineering. "Specifically, drugs could be used to target the synthetic lethal interaction partners of cancer-associated genetic mutations. These drugs would then effectively kill cancer cells but spare otherwise identical cells lacking the cancer-related genetic alteration."


Myers and his collaborators used research on yeast genes to find synthetic lethality, and then found genes in humans that were similar in structure and evolutionary origin to the yeast cells. Myers worked with Dr. Dennis Wigle, a practicing thoracic surgical oncologist at Mayo Clinic to test those interactions in human cells.


They found two striking cases where synthetic lethal interactions were similar between yeast and human cells. These interactions involve genes that are frequently mutated in specific types of cancer and provide potential new drug targets for these tumors.


"About 40 percent of yeast genes have homologs in humans, we thought that inferring interactions across species may provide a quick way of getting at these interactions," Myers said. "Given our expertise with the yeast interactions, we developed a strategy for narrowing down the large list of interactions to test, based on sequence similarity between the genes and public databases of genes commonly mutated in cancer as well as other features."


Decades of drug discovery research have produced a limited number of targeted therapies for treating cancer. The most commonly used therapies involve delivering high doses of radiation or toxic chemicals to the patient, which can help to suppress tumor growth but also cause substantial damage to normal tissue.


"The strategy of using synthetic lethal interactions to identify drug targets, particularly for 'undruggable' cancer genes is an attractive alternative method for drug target discovery," said Wigle. "This technology is an important means to fully leverage information from sequencing projects for clinical application."


###


To read the full research paper entitled "A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer," visit http://cancerres.aacrjournals.org/content/early/2013/10/04/0008-5472.CAN-12-3956.abstract.




[ Back to EurekAlert! ]

[


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| Share Share

]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/uom-rdn101413.php
Category: washington post   world war z   Whitey Bulger   Juan Pablo   Emmy nominations 2013